Study on the synthesis of isoamyl chloroacetate with SO_4~(2-)/ZrO_2/β

The solid super acid SO2-4/ZrO2/β was prepared by a co-precipitation impregnation method.Isoamyl chloroacetate was synthesized from chloroacetic acid and isoamyl alcohol using SO2-4/ZrO2/β as the catalyst.Influence of the choice of water-taking agent,the amount of water-taking agent,the molar ratio of acid to isoamyl alcohol,the amount of catalyst and reusability of catalyst on the esterification rate had been studied.Under optimum conditions:n(alcohol)∶n(acid)=1.5 ∶1,the amount of chloroacetic acid 0.15 mol,dosage of catalyst 0.6 g,the dosage of cyclohexane 10 mL,reaction time 100 min,the yield of esterification could reach 99.53%.Activity of catalyst changes little after being reused for six times.The results showed the catalyst SO2-4/ZrO2/β possessed fine activity and could be used abroadly.