Preparation and Quality Control of Ambroxol Hydrochloride Dispersible Tablets

Objective To study the preparation and quality control of ambroxol hydrochloride dispersible tablets. Methods UV spectrophotometry was used to detect dissolution of ambroxol hydroehloride dispersible tablets and HPLC was used to determine the content of ambroxol hydroehloride. Results The linear range of ambroxol hydrochloride was over 15-45 μg·mL-1.The average rate of recovery was 100.33% and RSD was 0.58%(n=9).The dissolution of 3 batches of samples were all above 86.0%. Conclusion The ambroxol hydrochloride dispersible tablets can disintegrate quickly in the water and disperse homogeneously.The preparation technology is reliable,simpl e and accurate,which can be used in producing and use of hospital preparations.