2011•International Journal of Cardiovascular DiseaseRequires access
Effects of atorvastatin on inflammatory level and clinical prognosis in patients with chronic congestive heart failure and paroxysmal atrial fibrillation
Xu Liu
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Abstract
Objective:To investigate the effects of atorvastatin on inflammatory level and clinical prognosis in patients with chronic congestive heart failure and paroxysmal atrial fibrillation(AF).Methods:A total of 135 patients with chronic congestive heart failure and paroxysmal AF were divided into atorvastatin group(72 cases) and control group(63 cases).During the 18 months' follow-up,CRP and serum lipid level,left atrial diameter and left ventricular function were measured.In addition,we also evaluated the recurrence of paroxysmal AF and the incidences of persistent and permanent AF,and cardiocerebral vascular events.Results:After atorvastatin treatment,the levels of CRP at 1-month,6-month,18-month were diminished significantly.Lipid levels were also improved markedly in atorvastatin group.During 18-month following-up,the recurrence of paroxysmal AF and incidence of persistent and permanent AF,and cardiocerebral vascular events were decreased in atorvastatin group.Conclusion:Atorvastatin could reduce the CRP level and decrease the recurrence of paroxysmal AF,and incidences of persistent and permanent AF,which also attenuated the cardiocerebral vascular events in follow-up.