The evaluation of nuchal translucency abnormality in 115 cases

Objective To evaluate the value of nuchal translucency(NT) in prenatal diagnosis of fetal chromosomal abnormality and malformation.Methods Between Jan.2008 and Dec.2010 in the Beijing Haidian Maternal and Child Health Hospital,fetal NT and development in 115 cases of singleton pregnancy were detected to abnormal in 11～13+6 weeks.Pregnancy outcomes of all women were followed up,and the NT≥3.0mm was abnormal.Results Normal delivery,abortion,termination of midtrimester pregnancy,occurred in 54,2,59 in these 115 cases.Only with NT thickening there were 94 ones,in these people 35 ones underwent fetal karyotype analysis(37.23%),severe malformation with NT thickening 21 ones,only 7 underwent fetal karyotype analysis(33.33%).There are 42 ones underwent fetal karyotype analysis in 115 cases,Chromosomal normality is 25 cases(59.52%),chromosomal abnormality is 17 cases(40.48%),trisomy 21,trisomy 18,Turner(45,Ⅹ) occurred in 11,4,and 2.Conclusion NT thickening may indicate the increased risk of fetal chromosomal abnormality,malformation,stillbirth and miscarriage.Through standard the value of NT and prenatal diagnosis to decrease the malformation.It was important to make a solid NT cutoff number for clinical consultation.