Pharmacokinetics comparison between amoxicillin dispersible tablets and amoxicillin tablets in healthy volunteers

Objective To develop a RP - HPLC method for determination of amoxicillin in human plasma and compare the pharmacokinetics of amoxicillin dispersible tablets and amoxicillin tablets in healthy volunteers.Methods Twelve healthy male volunteers were selected and divided into two groups,who received a single oral dose of 500 mg amoxicillin sustained release tablets and amoxicillin tablets respectively.The plasma concentrations of amoxicillin were determined by HPLC.Results The main pharmacokinetic parameters of amoxicillin sustained release tablets and amoxicillin tablets were as follows:C_(max) were(742.8±68.4)μg/L and(676.7±57.2)μg/L,t_(max) were(2.7±0.3) h and(3.4±0.6) h,t_(1/2) were(4.9±1.5) h and(5.9±1.8) h,AUC_0~∞were(6 417.3±167.5)μg/(h·L) and(4 704.8±117.9)μg/(h·L),AUC_0~t were(4 927.4±119.7)μg/(h·L) and(3 436.5±103.5)μg/(h·L) respectively.Conclusion The t_(max) and t_(1/2) of amoxicillin dispersible tablets were significantly smaller than that of amoxicillin tablets,AUC_0~t,AUC_0~∞and C_(max) were significantly higher than that of the amoxicillin tablets.It suggested that the amoxicillin dispersible tablets had a certain property of swift releasing,and it is obvious better than its ordinary tablets.