Pharmacokinetics of amoxicillin gastroretentive tablets in eight healthy volunteers

OBJECTIVE To study the pharmacokinetics of amoxicillin gastroretentive tablets.METHODS The pharmacokinetics of amoxicillin gastrorerentive tablets and conventional capsules were studied in 8 volunteers after a single oral administration of 750 mg respectively.The concentrations of amoxicillin in plasma were measured by HPLC.RESULTS The pharmacokinetic disposition was described by one compartment model.The elimination half life the test tablets and capsules were (2.29±0.65) h and (1.11±0.19) h, t max (2.69±0.46) h and (1.38±0.13) h, AUC 0～∞ (29.865±7.572) μg·h·mL -1 and (38.325±6.951) μg·h·mL -1 ,respectively.CONCLUSION The results showed that the tablets had a sustained release and long acting effect while the bioavailability was lower than that of the conventional capsules.