2007•Chinese journal of integrated traditional and Western medicineRequires access
Experimental Study on Effects of Qishen Yiqi Dropping Pills on Liver Fibrosis in Rats
Bao-en Wang
Open publisher page 1 citations
Abstract
Objective To investigate the anti-fibrotic effects of Qishen Yiqi Dropping Pills (QYDP) in rats with liver fibrosis (LF).Methods The LF model was induced by intraperitoneal injection with dimethylni- trosamine (DMN).Sixty Wistar rats were randomly divided into the normal group,the model group A,the QYDP intervened group,the model group B,and the QYDP treated group B.The degree of LF was evaluated according to 6-phase grading method.The expressions of collagen typeⅠandⅢand tissue inhibitor of metallo- proteinase-1 (TIMP-1) in liver tissues were determined by immunohistochemistry and the levels of collagen typeⅠandⅢand TIMP-1 mRNA determined by semi-quantitive RT-PCR.Results Compared with the model group A and B,the degree of LF,the positive expressions of TIMP-1 mRNA and the content of collagen typeⅠandⅢin liver tissue in the QYDP intervened and treated groups were significantly lower.Conclusion QY- DP could reduce the pathological changes and degree of LF in rats,which may be partially through inhibiting the expressions of collagen typeⅠandⅢand TIMP-1.