Analysis of blood coagulation indicators in childhood acute leukemia

Objective To discuss the changes and clinical significance of blood coagulation indicators in childhood acute leukemia.Methods The levels of APTT,PT,TT,FIB in serum were determined and Platelets(PLT) in 100 acute leukemia patients and compared with that in normal control group.Results A total of 58 case of ALL,PT,APTT,TT,FIB and PLT are(14.77±1.91)s、(41.82±9.06)s、(16.78±1.92)s、(3.38±1.74)g/L、50.00×109/L.Compared with the control group,the differences of APTT,FIB and PLT in ALL patients were significant(P equal 0.023,0.027,0.007,0.05).42 case of ANLL,PT、APTT、TT、FIB and PLT are(17.48±3.12)s、(44.34±9.90)s、(17.37±3.62)s、(2.33±1.30)g/L,19.00×109/L.Compared with the normal control group,the differences of the levels of PT,APTT,and PLT in ANLL patients were significant(P 0.01);The difference of PT,FIB and PLT in ALL patients shows significance(P 0.01),compared with ANLL patients.And the levels of PLT,PT and FIB were higher in patients with hemorrhage than nonhemorrhage(P 0.01),and there were no significant differences in APTT and TT(P equals 0.528 and 0.263).Conclusion Combined detection of blood coagulation index and plt count can provide important experimental evidences in Acute Leukemia typing and bleeding occurrence.