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Chemosensitivity Test of Human Head and Neck Tumors Cell Line with MTT Assay

Zhao De-ping

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Abstract

In vitro cell culture of head and neck tumors and chemosensitivity test to select sensitivity antitumor bogs for individual chemotherapy. Methods:The chemosensitivity of 32 fresh specimens of human head and neck tumors were tested with MTT assay and eight atitumor drugs. Results:The sensitivity was 84 4% for 5-Fu, 2l 9% for VCR, 62 5% for MTX, 8l 3% for BLM, 8l 3% for DDP, 40 6% for ADM, 65 6% for PYM and 3 l% for CTX. The results of chemotherapy with sensitivity drugs of 32 patients were encouraged. There were no serious side-effects in the chemotherapy and no recurrence and metastasis after the treatment. 32 patients were still alive. Conclusion: Chemosensitivity test of tumor cell lines with MTT assay was accuracy, fast,simple,ecoromical,effective method and was valuable for chemotherapy.

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What this paper is about

In vitro cell culture of head and neck tumors and chemosensitivity test to select sensitivity antitumor bogs for individual chemotherapy. Methods:The chemosensitivity of 32 fresh specimens of human head and neck tumors were tested with MTT assay and eight atitumor drugs. Results:The sensitivity was 84 4% for 5-Fu, 2l 9% for VCR, 62 5% for MTX, 8l 3% for BLM, 8l 3% for DDP, 40 6% for ADM, 65 6% for PYM and 3 l% for CTX. The results of chemotherapy with sensitivity drugs of 32 patients were encouraged. There were no serious side-effects in the chemotherapy and no recurrence and metastasis after the treatment. 32 patients were still alive. Conclusion: Chemosensitivity test of tumor cell lines with MTT assay was accuracy, fast,simple,ecoromical,effective method and was valuable for chemotherapy.

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Available abstract

In vitro cell culture of head and neck tumors and chemosensitivity test to select sensitivity antitumor bogs for individual chemotherapy. Methods:The chemosensitivity of 32 fresh specimens of human head and neck tumors were tested with MTT assay and eight atitumor drugs. Results:The sensitivity was 84 4% for 5-Fu, 2l 9% for VCR, 62 5% for MTX, 8l 3% for BLM, 8l 3% for DDP, 40 6% for ADM, 65 6% for PYM and 3 l% for CTX. The results of chemotherapy with sensitivity drugs of 32 patients were encouraged. There were no serious side-effects in the chemotherapy and no recurrence and metastasis after the treatment. 32 patients were still alive. Conclusion: Chemosensitivity test of tumor cell lines with MTT assay was accuracy, fast,simple,ecoromical,effective method and was valuable for chemotherapy.

Key concepts: MTT assay, Chemotherapy, Chemosensitivity assay, Medicine, Head and neck, Cell culture, Cancer research, Oncology

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