Expression of CD55 and CD59 in acute myeloid leukemia

Objective:To detect the expression of complement regulatory protein(CD55,CD59) on blasts of acute myeloid leukemia(AML). Method:Expression of CD55,CD59 in 203 previously untreated AML patients were analyzed by flow cytometry. Result:In all 203 AML patients' samples,the deficiency of CD59 expression were found in 83 samples.Deficiency of CD55 expression was found in 5 patients' samples(4 samples showed both CD55 and CD59 decrease).According to the WHO classification,the rates of CD59 expression deficiency found in different subtypes of AML were as following: AML-M2(16.7%),AML with t(8;21)(44.0%),AML with t(15;17)(67.92%),AML-M4(9.52%),AML with t(16;16)or inv(16)(92.31%),AML-M5(27.14%).Three AML with t(15;17) and one AML-M5 had been found the deficiency of both CD55 and CD59.Only one sample of AML-M4 had been found the deficiency of both CD55 and CD59.Compared with patients in other subtypes,the deficiency rates in prognostic favorable AML is higher. Conclusion:Deficiencies of CD55 and CD59 expression were detected in parts of AML patients,especially CD59 deficiency.The rates of CD59 expression deficiency was found higher in prognostic favorable AML than others.