Study on Pharmacokinetic Properties of Curcumin Derivative FM0807 in Mice under Different Drug Administration Manners

Objective To study the pharmacokinetic properties of FM0807 in mice under different drug administration manners.Methods HPLC was adopted to determine the plasma concentrations of FM0807 and curcumin in mice after received intravenous injection,intragastric administration of FM0807 respectively,and the pharmacokinetic parameters were calculated.Results Curcumin in mice was fitted to a two-compartment open model.After intravenous administration,the pharmacokinetic parameters were as follow:t1/2β 13.58 min,AUC 620.66 μg /(mL/min),Vd 2.59 L/kg,Cmax 62.11 μg/mL.After intragastric administration,the pharmacokinetic parameters were as follow:t1/2β 79.86 min,AUC 59.81 μg /(mL/min),Vd 317.35 L/kg,Cmax 0.50 μg/mL.Conclusion After intravenous administration,FM0807 is rapidly metabolized into curcumin in vivo,and the effective concentration in serum lasts 50 min.After intragastric administration,the concentration-time curves of curcumin exhibit double peaks,which may suggest the phenomenon of hepatoenteral circulation.