2014•PubMedRequires access
[Pharmacokinetics study of curcumin solid lipid nanoparticles by intravenous injection in rats].
Zijun Yan, Wanyu Li, Lili Sun, Xue Deng, Kun Wan, Jingqing Zhang
Open publisher page 1 citations
Abstract
OBJECTIVE: To study the intravenous pharmacokinetics of curcumin solid lipid nanoparticles in SD rats. METHODS: Rats were administrated with (iv) curcumin solid lipid nanoparticles and curcumin solution (8.0 mg/kg), respectively. Blood samples were collected and curcumin in blood plasma was determined by HPLC. Compartmental pharmacokinetics was analyzed by DAS software. RESULTS: After intravenous administration, the AUC(0-t), AUC(0-infinity) and t(1/2) of curcumin solid lipid nanoparticles were 1.50-fold, 1.63-fold and 4.08-fold higher than those of curcumin solution as (173.09 ± 44.81) μg x h/L vs. (114.83 ± 13.19) μg x h/L, (196.56 ± 35.25) μg x h/L vs. (120.66 ± 13.95) μg x h/L and (5.95 ± 2.05) h vs. (1.46 ± 0.03) h. CONCLUSION: The curcumin solid lipid nanoparticles is eliminated more slowly. The bioavailability of curcumin in rats increases remarkably compared with that of curcumin solution after intravenous administration.