2011•Xiandai shengwu yixue jinzhanRequires access
Efficacy of Adefovir Dipivoxil and Lamivudine on Treatment of Hepatitis B Related Cirrhosis with DNA Positive
Wan Mo
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Abstract
Objective:To investigate efficacy of adefovir dipivoxil and lamivudine on treatment of hepatitis B related cirrhosis with DNA positive.Methods:46 patients with liver cirrhosis and HBV DNA positive were randomly divided into the control group and observation group.Based on the symptomatic treatment,the observation group(22 patients) were treated with adefovir dipivoxil combined with lamivudine,and the control group(24 patients) were treated with adefovir dipivoxil.The total course of treatment was 48 weeks.Results:After 12 weeks of treatment,HBV DNA negative conversion rate of the observation and control group were 54.5% and 20.8%,respectively(P0.05).ALT normalization rate of the observation and control group were were 63.6% and 33.3%,respectively(P0.05).After 24 weeks and 48 weeks of treatment,the above indexes showed no significant difference between the two groups.No significant adverse drug reactions were found in the two groups.Conclusion:On treatment of hepatitis B related cirrhosis with DNA positive,adefovir dipivoxil combined with lamivudine shows rapid onset,good effect in reducing viral load and good security.