The control study of homemade sertraline versus clomipramine in treatment of obsessive-compulsive disorder

Objective To evaluate the therapeutic effect and safety of homemade sertraline and clomipramine in treatment of obsessive-compulsive disorder.Methods Fifty patients according to CCMD-3 criteria were enrolled in this study.Twenty-five patients taking Sertrline and another twenty-five patients having Clomipramine for eight weeks.Symptom improvement and side effects were monitored with clinical evaluation,Yale-Bown OCD rating scale,MSCPOR,HAMD,HAMA and TESS.Results At the end of eight weeks of treatment,there was no significant difference in the efficacy between sertraline and clomipramine.However the side effects of sertraline were lighter than clomipramine.Conclusion The results indicate that both sertraline and clomipramine is effective in the treatment of OCD,but sertraline showed more advantages for its convenient administration and the side effects of it were light.