Analysis on pathogenic epidemiology of AFP in Guangdong, 2001

Objective To analyze pathogenic epidemiology of AFP (acute flaccid paralysis) cases in Guangdong in 2001. Virus isolation and identification of AFP cases feces specimen was conducted with RDa and L20B cells. Immunization history, sex, age and 60 days follow- up result of AFP cases were compared with the virus identified. Results The feces specimens of 288 AFP cases were collected, and 28 PV(poliovirus) strains were isolated, with 9.7% of the positive rate. All of them were vaccine strains, of which 15 strains were PVII ( predominant strains) . 21 NPEV isolated were obtained with 7.3% of positive rate. The PV isolated rate of AFP cases with zero - dose OPV immunization was 50.0% (9/18) and which was high than that of the cases with 1 -2 doses and ^3 doses. The PV isolation rate was 27.3% in the 22 cases of indeterminable residual paralysis, higher than that in other cases, and of which PVII isolation was the highest with the rate of 22.7%(5/22) .Conclusion No polio case caused by wild poliovirus was found in Guangdong province in 2001. The PVII might be the causes of part of AFP cases uncompleted OPV immunization.