Synthesis of n-Amyl Salicylate Catalyzed by Sodium Hydrogen Sulfate

n-Amyl salicylate was synthesized from salicylic acid and n-pentanol using sodium hydrogen sulfate as catalyst.Factors influencing the ether yield,such as molar ratio of alcohol to acid,catalyst dosage,reaction time,water carrier dosage were discussed.Experimental results showed that sodium hydrogen sulfate was an excellent catalyst.The optimum synthetic conditions were as follows: molar ratio of salicylic acid to n-pentanol was 1∶1.5,catalyst dosage was 4.7% of mass of the reactants,using 10 mL of cyclohexane as water carrier,reaction temperature was 120~140℃ and reaction time was 4.5 h.Under above conditions,the yield of n-amyl salicylate achieved 93.3%.