Comparative Study of Sufentanil and Fentanyl on Patients Undergoing Thoracic Surgery

Objective To evaluate the clinical efficacy of sufentanil and fentanyl at equivalent dose for patient-controlled intravenous analgesia(PCIA) after thoracotomy.Methods Forty patients undergoing thoracic surgery were randomly divided into sufentanil intravenous analgesia group and fentanyl intravenous analgesia group.The pain intensity according to VASr,VASm,the observer's assessment of alertness/sedation(OAA/S),cumulative analgesic consumption,PCIA button pressing times and side effects at 24 and 48 hours after administration were recorded.SpO2,respiratory rate,ECG and blood pressure were continuously monitored.Results There were no significant differences in CAC,RR,heart rate and mean arterial pressure between the two groups(P0.05).But the VASr and VASm were lower in sufentanil group than in fentanyl group(P0.05).And the SpO2,OAA/S,PCIA button pressing times,occurrence rate of adverse reaction were superior in sufentanil group(P0.05).Conclusion PCIA with sufentanil provides better efficacy of analgesia and sedation than with fentanyl in postoperative patients with thoracotomy.