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[Chromosome karyotype and Y chromosome microdeletion analysis in 133 idiopathic male infertile patients].

Yan Ji, Hong-jia Xu, Jian-chu Huang

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Abstract

OBJECTIVE: To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients. METHODS: Karyotypic analysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis. RESULTS: Of the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions. CONCLUSION: The chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.

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What this paper is about

OBJECTIVE: To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients. METHODS: Karyotypic analysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis. RESULTS: Of the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions. CONCLUSION: The chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.

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Available abstract

OBJECTIVE: To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients. METHODS: Karyotypic analysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis. RESULTS: Of the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions. CONCLUSION: The chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.

Key concepts: Karyotype, Y chromosome microdeletion, Chromosome, Biology, Male infertility, Y chromosome, Chromosome analysis, Marker chromosome

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[Chromosome karyotype and Y chromosome microdeletion analysis in 133 idiopathic male infertile patients]. — Research Paper | ScholarLens