The effect of Weichangshu on plasma MTL,SP and SS in rats of gastrointestinal motility disorder

Objective To investigate the mechanism of Weichangshu promots gastrointestinal motility.Methods Select SD rats were randomly divided into normal control group,L-Arg group,L-Arg plus Weichangshu group and L-Arg plus xishabili group.In addition to the normal control group,the other three groups were Intraperitoneal injected L-Arg,Each group was given equal volume of drug administered,abdominal aortic blood,radioimmunoassay determination of plasma MTL,SP,SS content.Results L-Arg model contral group MTL,SP,SS were significantly lower,compared with the normal contral group(P0.01).After treatment,Weichangshu group MTL,SP,SS in plasma increased significantly,compared with L-Arg model contral group(P0.05).Conclusion The mechanism of Weichangshu promote gastrointestinal motility is may be:①Regulate plasma gastrointestinal hormone balance and facilitate the coordination,then Promote gastrointestinal motility.②Elevate levels of plasma MTL and SP,Increase Ca2+ concentration within gastrointestinal smooth muscle cells,Ca2+ signal system trigger a series of physiological functions and then promote the effect of gastrointestinal smooth muscle contraction.