Influence of Acute Hypervolemic Hemodilution on Blood Coagulation And Renal Function in Geriatric Patients

Objective:To investigate the influence of AHH on blood coagulation and renal function in geriatric patients.Methods:Thirty patients aged 60 yr undergoing elective surgery were randomly divided into three groups.AHH was administrated with HES or LR in group A and B. AHH was not administratedin group C.PT、APTT、FIB、BUN、CR and NAG were measured at T_1(before AHH)、T_2(over AHH)、T_3(after AHH for sixty minutes)、T_4(after operation) and T_5(in the morning of the first day after operation).Result:APTT of group A at T_2 and T_3 was significantly longer than that at T_1(P0.05).There were no significant difference on FIB and APTT among groups at all time points but the FIB at T_5 were significantly higher than that at T_1 in three groups(P0.05).Serum concentrations of CR and BUN were normal during the study.NAG at T_3～T_5 were higher than that at T_1 (P0.05)and there was no significant difference among groups.The differences on blood transfusion between three groups were singnificant(P0.05).Conclusion:Prioperative AHH with HES have no obvious harmful effect on blood coagulation,renal function and hemodynamics in geriatric patient.It can effectively reduce blood transfusion.