Influence of acute hypervolemic hemodilution with different intravascular volume replacement on blood coagulation and renal function in elderly patients

Objective. To investigate the influence of acute hypervolemic hemodilution (AHH) with different intravascular volume replacement on blood coagulation and renal function in elderly patients. Methods. Thirty patients (aged > 60 years and < 75 years) were randomly divided into three groups. AHH was administrated with 6% HES (200/0.5) and 4% gelofusine in group A and B, respectively. AHH was not administrated in group C. PT, APTT, FIB, BUN, CR and NAG were measured at T1 (before AHH administration), T2 (at the end of AHH ), T3 (60 minutes after AHH), T4 (at the end of surgery ) and T5 (on the first morning after surgery). Results. APTT of group A at T2 and T3 was significantly longer than that at T1 ( p < 0.05). There were no significant differences of FIB and APTT among groups but the FIB were significantly higher at T5 than that at T1 in three groups (p < 0.05). Serum concentrations of CR and BUN were normal during the study. NAG at T3 – T5 were higher than that at T1 and reached peak at T4 and there was no significant difference among groups. Conclusion. Preoperative AHH with HES or gelofusine has no detrimental effect on blood coagulation and renal function in elderly patients. [Life Science Journal. 2008; 5(4): 38 – 40] (ISSN: 1097 – 8135).