Comparison of clinical effects between rosiglitazone and pioglitazone in the treatment of type 2 diabetes of eldly patients

AIM To compare the clinical effects of rosiglitazone with pioglitazone in the treatment of type 2 dia- betic patients.METHODS Sixty-four patients who had been treated with food control,exercise and fixed oral anti-dia- betic drugs for one month,but their fasting plasma glucose level was still over 7 mmol·L~(-1).They were randomized divid- ed into two groups.One was added with rosiglitazone,the other was added with pioglitazone.All of them were treated for 12 weeks.RESULTS After treatment for 12 weeks,①patient's fasting plasma glucose,postprandial plasma glucose, HbA_(?)c and insulin resistance index were significant decreased in both groups;②triglyceride and total cholesterol were decreased in pioglitazone group(P0.05),but those in rosiglitazone group were no significant reduction(P0.05);③high density lipoprotein-cholesterol was elevated in both groups(P0.05).CONCLUSION Rosiglitazone or pioglita- zone can be used to control blood glucose,but pioglitazone shows more efficiency on triglyceride control.