Escherichia Coli Distribution and Analysis of Antibiotic Resistance in Urinary Tract Infection

[Objective] To analyze the distribution features of Escherichia coli(E.coli)and antibiotic resistance in urinary tract infection,and provide the reference for clinical use of antibiotic.[Methods]BIO MERIEUX VITEK2-Compact microbial analyzer was used for identification and antibiotic sensitivity test.652 strains of E.coli isolated from inpatients and outpatients with urinary tract infection during April 2008-April 2010 were collected for sensitivity analysis and ESBLs detection.[Results]The isolation rate of ESBLs producing E.coil was 38%.Drug sensitivity results showed that the resistance rate of E.coli was lower to amikacin,nitrofurantoin,meropenem,imipenem,while that was up to 60% to penicillins,ciprofloxacin,levofloxacin,and gentamicin.The resistance rate was significantly higher in ESBLs producing strains than in non-ESBLs producing strains.The resistance rate was higher in strains from inpatient than from outpatient.[Conclusion]The drug resistance of E.coli in urinary tract infection is extremely severe,especially for ESBLs-positive strains.It is necessary to enhance resistance surveillance,to guide clinical medication so as to slow down the appearance of drug-resistant strains.