Effects of xuebijing injection on organ function and mortality in rats with sepsis

[Objective] To investigate the effects of Xuebijing(cleaning the blood) injection on the multiple organ function and mortality in rats with sepsis.[Methods] Sepsis was reproduced in rats with cecum ligation and puncture(CLP).Ninety-six male Wistar rats were randomly divided into normal control group(n=8),sham-operation group(n=8),CLP model group(n=40),Xuebijing-treated group(n=40).The two latter groups were further divided into five groups of 2,8,24,48,and 72-hour subgroups with 8 rats in each.In addition,another experiments were performed to observe the effect of treatment of Xuebijing on the survival rate.[Results] Serum levels of ALT,AST,blood urea nitrogen(BUN),creatinine(Cr),creatine kinase(CK) and MB isoenzyme of creatine kinase(CK-MB) were significantly increased with certain extent at different intervals.Early treatment with Xuebijing could markedly improved serum biochemical parameters partly.Treatment with Xuebijing or/and antibiotic could significantly improve the survival rates in septic rats.[Conclusion] These findings indicates that Xuebijing injection can obviously decline the mortality of septic rats,and has played an important role in protecting against the multiple organ dysfunction.