The clinical significance of RAD51 G135C polymorphysm and p53 mutation in non-small cell lung cancer

Purpose To investigate the relationship between RAD51 G135C polymorphism and lung cancer risk,pathological characteristic,and p53 mutation in lung cancer.Methods A total of 80 lung cancer cases and 40 controls with lung non-neoplastic diseases were collected.We analyzed the genotypes of RAD51(G135C) by PCR-RFLP and determined their association with lung cancer risk and pathological characteristic,and we detected the p53 mutation of 80 lung cancer cases by immunohistochemistry.Results(1)The frequency of G/G,G/C and C/C genotype was 83.7%,15.0% and 1.3% in cases and was 92.5%,7.5% and 0 in controls.When G/G served as the reference group,variant genotype(G/C and C/C) had a significantly increased risk of lung cancer(P0.05).(2)There were no significant difference between the genotype of RAD51 and the pathological type and grade(P0.05).(3)There were no significant difference between the distribution frequency of the genotypes of RAD51 and different p53 mutation status in lung cancer(P0.05).Conclusion RAD51 G135C gene polymorphism may be a risk factor for lung cancer and the person who carry the variant genotype(G/C and C/C) had a significantly increased risk of lung cancer.