Analysis of the distribution and drug susceptibility of 371 fungi strains resulting in deep infections.

Objective To investigate the distribution and drug resistance situation of the fungi which caused deep part infection. Methods The isolated fungi were indentified with API 20C AUX and drug susceptibility tests was conducted by using ATB FUNGUS. Results 228 strains of Candida albicans, 73 strains of Candida tropicalis, 38 strains of Candida glabrata, 12 strains of Candida papasilosis, 6 strains of Candida famata, 3 strains of Cryptococcus neofermans, 3 strains of Candida inconspicua, 2 strains of Candida guilliermondii were isolated. The total sensitivity of 371 strains of fungi to 5-fluorocytosine, amphotericin B, mycomycin, miconazole, econazole, ketoconazole were 92%,97%,96%,57%,63%,69%,respectively. Conclusion The dominant pathogenic fungi which caused deep part infection were Candida albicans, Candida tropicalis and Candida glabrata. Amphotericin B, mycomycin and 5-fluorocytosine were most sensitive to the pathogenic fungi and remain to be the most effective drug to cure deep part infection.