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2002•Journal of Modern StomatologyRequires access

Study on the correlation between metalloproteinase-2 and neck lymph node metastasis of oral squamous cell carcinoma

Yaxin Li

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Abstract

Objective To detect the correlation between metalloproteinase-2 and neck lymph node metastasis of oral squamous cell carcinoma.Methods Zemography was used to study the content of MMP-2 in OSCC,and statistical method was used to analyse the association between the content of MMP-2 matrix metalloproteinases and the invasive and metastatic clinical and pathological index of OSCC.Results The results showed that MMP-2 existed in all the OSCC tumor tissues,normal oral mucosa member and plasma,and that the increase of the content of MMP-2 in both the tumor tissue and plasma related to tumor invasion and neck lymph node metastasis.Conclusion MMP-2 could be considered as an index judging preasence of neck lymph node metastasis.

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What this paper is about

Objective To detect the correlation between metalloproteinase-2 and neck lymph node metastasis of oral squamous cell carcinoma.Methods Zemography was used to study the content of MMP-2 in OSCC,and statistical method was used to analyse the association between the content of MMP-2 matrix metalloproteinases and the invasive and metastatic clinical and pathological index of OSCC.Results The results showed that MMP-2 existed in all the OSCC tumor tissues,normal oral mucosa member and plasma,and that the increase of the content of MMP-2 in both the tumor tissue and plasma related to tumor invasion and neck lymph node metastasis.Conclusion MMP-2 could be considered as an index judging preasence of neck lymph node metastasis.

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Available abstract

Objective To detect the correlation between metalloproteinase-2 and neck lymph node metastasis of oral squamous cell carcinoma.Methods Zemography was used to study the content of MMP-2 in OSCC,and statistical method was used to analyse the association between the content of MMP-2 matrix metalloproteinases and the invasive and metastatic clinical and pathological index of OSCC.Results The results showed that MMP-2 existed in all the OSCC tumor tissues,normal oral mucosa member and plasma,and that the increase of the content of MMP-2 in both the tumor tissue and plasma related to tumor invasion and neck lymph node metastasis.Conclusion MMP-2 could be considered as an index judging preasence of neck lymph node metastasis.

Key concepts: Matrix metalloproteinase, Medicine, Pathological, Metastasis, Pathology, Lymph node metastasis, Matrix metalloproteinase 9, Lymph node

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