The clinical observation of blood coagulation function in patients with chronic cor pulmonale during acute attack

Objective To observe the changes of the trombina(coagulation) function in patients with cor pulmonale during acute stage.Methads 61 cases with cor pulmonale during acute stage were divided into three groups according to their disease course: the severe, moderate and mild group and 55 healthy cases were collected as control. Thrombin time (TT), prothrombin time (PT), prothrombin ratio(PT/R), content of fibrinogen (Fbg) and activated partial thromboplastin time(APTT) were measured in all samples.Results Data of the TT, PT, APTT and PT/R in patients with the cor pulmonale were lower than those in the control group (P0.01 P0.005), and each data decreased when state of illness became severe, whereas, the Fbg content was higher than that of control group and increased when state of illness became severe.Conclusion The bloods of patients with the cor pulmonale during acute stage were in hyper coagulation state that was related to severity of disease. Recognizing and correcting the changes were helpful to reduce the fatality rate.