Advances on Therapeutic Monoclonal Antibody

Hybridom techniques have made mouse monoclonal antibody widely use in diagnosis and research of human disease, and established the first milestone of therapeutic antibody.But subsequent side effects such as HAMA response greatly limits the clinical application of mouse antibody.With the biology development and antibody genetic structure clarification, people can humanize mouse antibody with DNA recombination and antibody library which developed antibody techniques from chimeric and reshaped to human antibody, and now variety of monoclonal antibody derivatives.Both humanized monoclonal antibody and its derivative overcome the clinical shortage of mouse antibody from different angles, also bring a new dawn to human disease.In this text, we summarized the progress on the humanization of therapeutic antibody.