Investigation on Distribution of Population with Impaired Glucose Regulation and Analysis of Risk Factors in Yanji Community in Shanghai

Objective To study the constituent ratio and risk factors of impaired glucose regulation (IGR) in elderly subjects of Yanji community. Methods A group of 2 228 randomly selected adults, aged 45-74 years and living in the Yanji community in Shanghai, were measured by fasting plasma glucose (FPG) screening. All cases were taken questionnaire survey, physical examination, fasting plasma glucose (FPG) and 2-hour postprandial plasma glucose (2 h PG) testing, and serum lipid profiles measurements. Total 393 cases were screened out as the patients with IGR. Results In the population with data integrity, NGT accounted for 39.19%, impaired fasting glucose (IFG) accounted for 12.72%, impaired glucose tolerance (IGT) accounted for 16.54%, impaired fasting glucose combined with impaired glucose tolerance (IFG/IGT) accounted for 16.03% and DM accounted for 15.52%. The constituent ratio of NGT, IFG, IGT, IFG/IG and DM was distinct in different aged groups (χ2=21.295, P=0.006). The proportion of IGT, IFG/IGT and DM increased with age while IFG didn’t. The constituent ratio of NGT, IFG, IGT, IFG/IGT and DM was distinct in different body mass index (BMI) groups (χ2=26.155, P=0.01).The ratio of abnormal glucose metabolic rise with BMI. Logistic regression analysis revealed that the main risk factors of IGR were family history of DM(OR=1.945), history of hypertension (OR=1.884), high triglycerides (OR=1.469), age (OR=1.038). Conclusion IFG/IGT and IGT is the most common IGR subcategory in Yanji community. The frequencies of IFG/IGT and IGT increase with age. Family history of DM, history of hypertension, high triglyceride and age are main risk factors of IGR.