Clinial eff icacy of 0.03% tacrolimus ointment for atopic blepharitis

Objective To investigate the clinical efficacy of 0.03% tacrolimus ointment in patients with atopic blepharitis.Methods Twenty-six patients were treated with 0.03% tacrolimus ointment twice a day for 2 weeks,and the clinical symptom and sign scores were recorded before and after treatment.Results The clinical cured rate was 57.69%,76.94%,92.30% and 73.08% at the 3th day,7th day,14th day and 30th day after treatment respectively.Among a variety of skin lesions,the therapeutic effect was better for erythema and itching than that for xerosis cutis and thickening.Four cases(15.38%) were reported to have local burning,which all happened in the first 3 days of treatment.There are 7(26.92%) patients who recurrent after withdraw of the treatment.Conclusion 0.03% tacrolimus ointment is an effective treatment option for the patients with atopic blepharitis.Long-term efficacy and safety of the medicine have to be evaluated by long-term follow-up studies.