PNS on Collagen in Lung Tissue of Lung Fibrosis in Rats

Objective: To study the PNS on pulmonary fibrosis in mice lung tissue collagen.Methods: C57BL/6 male mice were 180,divided into sham operation group,model group,PNS high,medium and low dose group,prednisone group,n = 30.In addition to the sham operation group,the remaining mice a single intratracheal instillation of bleomycin hydrochloride,sham operation group were a single intratracheal instillation with saline.2 days after modeling,starting dose,until the day before the animals were killed.PNS high,medium and low dose group were 120,60,30mg/kg/d,prednisone group was 0.56mg/kg,sham operation group,model group were given equal volume of saline.All the animals at 7,14,28 d were killed 10 lungs were taken for HE,Mallory staining,and determination of lung hydroxyproline(HYP) content.Results: PNS could reduce pulmonary fibrosis in mice with collagen content of lung tissue,reduce the proliferation of fibrous lung tissue.Conclusion: PNS can reduce pulmonary fibrosis in mice with collagen content of lung tissue play a role in treating pulmonary fibrosis.