2012•Zhongguo linchuang xinlixue zazhiRequires access
An Animal Model of Chronic Predator Stress-induced Behavioral Sensitization to Morphine
Zhang Yue-juan
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Abstract
Objective: To establish an animal model of chronic predator stress-induced behavioral sensitization to morphine.Methods: 16 rats were randomly divided into 2 groups: chronic stressed and controlled group.Locomotor activity was assessed 24h after the last stress in an activity recording system for 20 minutes.After acute morphine administration,locomotor activity was recorded for 120 minutes.Results: Chronic predator stressed rats showed less locomotor activity responding compared with controlled rats 24h after the last stress,but the difference was not significant statistically.Chronic predator stressed rats showed enhanced locomotor activity compared with controlled rats after acute morphine administration.Conclusion: Chronic predator stress can enhance the locomotor response to morphine in rats,which suggests chronic predator stress model could be an important model for the research in the vulnerability of drug addiction.