2004•Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences)Requires access
Effect of corticosterone on morphine-induced psychomotor effect and its sensitization
Wang Dm, Chia‐Yang Liu, Li Yh, XG Zheng, Nan Sui
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Abstract
Previous research demonstrated important roles of stress in behavioral effects of drug abuse. However, whether extraneous stress factors could differentially modulate morphine psychomotor effect and its sensitization is still unknown. This study examined the influence of corticosterone on the acute effect of morphine and its sensitization. Morphine (2 mg.kg-1 i.p.) enhanced the locomotor activity and formed behavioral sensitization upon repeated exposure. Corticosterone (5 mg.kg-1 i.p.) increased morphine psychomotor effect but played null role in the modulation of its sensitization. These results indicated that stress exposure promoted morphine acute psychomotor effect but did not affect the development of morphine sensitization.