Influence of Enteral Nutrition and Total Parenteral Nutrition on Clinical Efficacy and Immune Function of Patients with Severe Acute Pancreatitis

Objective To discuss the influence of enteral nutrition( EN) and total parenteral nutrition( TPN) on clinical efficacy and immune function of patients with severe acute pancreatitis( SAP). Methods Seventy- two SAP patients admitted to this hospital from February 2009 to February 2012 were divided randomly into groups EN and TPN,36 in each. Clinical effects,occurrences of complications and levels of serum IgA,IgG,IgM were compared between the two groups. Results In EN group,19 were cured,10 had effects,7 had no effects; In TPN group,16,12,8,respectively. The difference was not significant( u =- 0. 586,P 0. 05). Incidence of infection was lower in EN group than( 7 /36) in TPN group( 14 /36)( χ2= 3. 294,P 0. 05). Serum IgA,IgG,IgM were higher in EN group than in TPN group after 7 days of treatment( P 0. 05). Conclusion There is no significant difference in the influence of EN and TPN on the clinical effects of SAP patients.Compared with TPN,EN is favourable to reducing incidence of infection and improves patients' immune function. SAP patients without intestinal obstruction should undergo EN as soon as possible.