Influence of obesity and overweight on blood coagulation and metabolic indexes in patients with type 2 diabetes mellitus

Objective:To study influence of overweight and obesity on blood coagulation and metabolic disorders in patients with type 2 diabetes mellitus(T2DM).Methods: total of 248 preliminary diagnosed T2DM patients were selected.According to body mass index(BMI),they were divided into normal BMI control group(n=95),overweight group(n=87) and obesity group(n=66).Blood lipids,blood glucose and fasting insulin(FINS) were measured in all patients and homeostasis model-insulin resistance index(HOMA-IR) was calculated then.Statistical analysis was performed.Results:Compared with normal BMI control group,there were significant increase in fibrinogen [(3.37±0.55) g/L vs.(4.04±0.70) g/L vs.(5.20±0.69) g/L],urine microalbumin [(14.46±8.90) mg/g vs.(47.33±42.54) mg/g vs.(104.45±60.78) mg/g],fasting blood glucose [(7.15±0.97) mmol/L vs.(8.84±1.81) mmol/L vs.(10.06±2.28) mmol/L],FINS [(10.09±8.21) IU/ml vs.(14.33±15.55) IU/ml vs.(19.69±10.86) IU/ml],HOMA-IR[(3.19±2.59) vs.(5.51±5.38) vs.(8.48±4.62)],TG,TC and LDL-C levels in overweight group and obesity group,and the more BMI patients were,the higher these indicators were;There were significant decrease in plasma prothrombin time [(13.33±0.69)s vs.(12.74±0.69)s vs.(11.43±0.53)s],activated partial thromboplastin time [(37.32±2.31)s vs.(36.55±2.41)s vs.(34.61±1.53)s] and HDL-C [(1.54±1.12) mmol/L vs.(1.27±0.41) mmol/L vs.(1.09±0.28) mmol/L] in overweight group and obesity group(P0.05 all).Conclusion:Overweight and obesity aggravate coagulation and metabolic disorders in patients with type 2 diabetes mellitus.It also aggravates degree of insulin resistance,the more BMI patients are,the more serious they are.