Value of B-type natriuretic peptide in predicting short-term prognosis for patients with cardiovascular disease

Aim: To explore the value of B-type natriuretic peptide (BNP) inpredicting short-term prognosis for patients with cardiovascular disease. Methods: A total of 107 inpatients with cardiovascular disease, whose blood BNP concentration was measured with BIOSITE Triage BNP test within 1~3 days of admission, were divided into 2 groups according to the results of 1 month follow-up: the survival group(n=90) and the non-survival group(n=17). Results: The blood BNP concentration in the non-survival group was significantly higher than that in the survival group (the medians were 1 132 ng/L vs 116 ng/L, P0.000 5); the blood BNP concentration was positively correlated with heart rate, left ventricular end-diastolic dimension,history of cardiac failure and myocardial infarction (r was 0.28,0.49,0.39,0.21,respectively,P0.05), and negatively correlated with left ventricular ejection fraction(r=-0.63,P0.000 5);area under the curve of the receiver operating characteristic (ROC) of BNP to predict cardiac death within 1 month was 0.89, and 95% confidence interval was 0.79~0.98,P0.000 5; stepwise logistic regression analysis indicated that BNP(≥ 755 ng/L) were the only independent predictor of 1 month cardiac death(OR=17.6, and 95% confidence interval was 8.7~66.5, P 0.000 5).Conclusion: Blood BNP level is closely correlated with the short-term prognosis of inpatients with cardiovascular disease,and can be used to predict occurrence of cardiac death within 1 month.