Treatment of hospital-acquired pneumonia induced by drug-resistant Acinetobacter baumannii with carbapenem and sulbactam

Objective To observe the clinical effect of Carbapenems combined with sulbactam on hospital-acquired pheumonia(HAP) caused by carbapenem-resistant Acinetobacter baumannii.Methods Seventeen patients diagnosed with HAP caused carbapenem-resistant Acinetobacter baumannii were treated with carbapenems combined with sulbactam(imipenem and cilastatin sodium 0.5g iv(once 6h) or meropenem 0.5g iv(once 6h)combined with sulbactam 1g iv(once 8h) in our hospital from October 2007 to April 2009.Their clinical features at onset of the disease,therapeutic reactions at the endpoint and 30-day mortality were recorded.Results The Acinetobacter baumannii strains isolated from the patients were resistant to carbapenems with a resistant rate to ciprofloxacin,amikacin and minocycline of 100%,94.1%,and 70.6%,respectively.HAP was improved in 14 patients after 3-day treatment and in 11 patients at the end of treatment(EOT).Three patients died of HAP after 30 days.Conclusion Carbapenems combined with sulbactam have a good therapeutic effect on HAP.