Therapeutic effect of reduced glutathione on systemic inflammatory response syndrome with severe trauma

OBJECTIVE To observe the therapeutic value of the reduced glutathione(GSH) in critical illness cases with systemic inflammatory response syndrome(SIRS)after severe trauma.METHODS The 60 SIRS patients according to the diagnosis criteria of SIRS were randomly divided into regular treatment group(group B) and GSH treatment group(group A).The efficacy of the therapy in both groups were assessed and inflammatory cytokinases TNF-α,IL-6 and IL-10 levels were measured on admission in both of the groups. RESULTS SIRS markers all reduced more significantly in group A than that of in group B.The MODS incidence,TNF-α,IL-6 and IL-10 levels reduced more significantly in group A than that of in group B.CONCLUSION GSH improved significantly the clinical effects of SIRS, prohibited the inflammatory cytokinases and raised the anti-inflammatory cytokinases in the treatment of SIRS.