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2009•Chinese Journal of General PracticeRequires access

Clinical Study of the Therapeutic Value of the Reduced Glutathione in Systemic Inflammatory Response Syndrome(SIRS)

Lei Jian-hong

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Abstract

Objective To observe the therapeutic value of the reduced glutathione in critical illness cases with SIRS.Methods 48 SIRS patients were randomly divided into regular treatment group(group B)and reduced glutathione treatment group(group A).The efficacy of the therapy in both the groups were assessed and serum levels of CRP,TNF-α,IL-6 and IL-10 were measured on admission and the fifth day.Results SIRS markers all reduced more significantly in group A than in group B(P0.01).Serum CRP,TNF-α and IL-6 levels reduced more significantly in group A than in group B(P0.01).Conclusion Reduced glutathione significantly improved the clinical effects of SIRS,prevented the MODS incidence.

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What this paper is about

Objective To observe the therapeutic value of the reduced glutathione in critical illness cases with SIRS.Methods 48 SIRS patients were randomly divided into regular treatment group(group B)and reduced glutathione treatment group(group A).The efficacy of the therapy in both the groups were assessed and serum levels of CRP,TNF-α,IL-6 and IL-10 were measured on admission and the fifth day.Results SIRS markers all reduced more significantly in group A than in group B(P0.01).Serum CRP,TNF-α and IL-6 levels reduced more significantly in group A than in group B(P0.01).Conclusion Reduced glutathione significantly improved the clinical effects of SIRS,prevented the MODS incidence.

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Available abstract

Objective To observe the therapeutic value of the reduced glutathione in critical illness cases with SIRS.Methods 48 SIRS patients were randomly divided into regular treatment group(group B)and reduced glutathione treatment group(group A).The efficacy of the therapy in both the groups were assessed and serum levels of CRP,TNF-α,IL-6 and IL-10 were measured on admission and the fifth day.Results SIRS markers all reduced more significantly in group A than in group B(P0.01).Serum CRP,TNF-α and IL-6 levels reduced more significantly in group A than in group B(P0.01).Conclusion Reduced glutathione significantly improved the clinical effects of SIRS,prevented the MODS incidence.

Key concepts: Medicine, Systemic inflammatory response syndrome, Glutathione, Internal medicine, Gastroenterology, Group B, Group A, Inflammatory response

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