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HPLC Determination of Amlodipine Besylate and Lisinopril in Compound Amlodipine Tablets

Jing Yao

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Abstract

Objective: To establish an HPLC method for determining amlodipine besylatete and lisinopril in compound amlodipine tablets.Methods: HPLC analysis was carried out by gradient elution.The flow rate was 1.8 mL·min-1,and the detection wavelength was 210 nm.Results: The calibration curves for amlodipine and lisinopril were linear between the ranges of 10～200 μg·mL-1 and 20～400 μg·mL-1,respectively.The average recoveries(n=5) were 100.8%±0.78% and 101.3%±0.60%.Conclusion: This method is accurate,convenient and suitable for determining amlodipine besylatet and lisinopril simultaneously.

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What this paper is about

Objective: To establish an HPLC method for determining amlodipine besylatete and lisinopril in compound amlodipine tablets.Methods: HPLC analysis was carried out by gradient elution.The flow rate was 1.8 mL·min-1,and the detection wavelength was 210 nm.Results: The calibration curves for amlodipine and lisinopril were linear between the ranges of 10～200 μg·mL-1 and 20～400 μg·mL-1,respectively.The average recoveries(n=5) were 100.8%±0.78% and 101.3%±0.60%.Conclusion: This method is accurate,convenient and suitable for determining amlodipine besylatet and lisinopril simultaneously.

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Available abstract

Objective: To establish an HPLC method for determining amlodipine besylatete and lisinopril in compound amlodipine tablets.Methods: HPLC analysis was carried out by gradient elution.The flow rate was 1.8 mL·min-1,and the detection wavelength was 210 nm.Results: The calibration curves for amlodipine and lisinopril were linear between the ranges of 10～200 μg·mL-1 and 20～400 μg·mL-1,respectively.The average recoveries(n=5) were 100.8%±0.78% and 101.3%±0.60%.Conclusion: This method is accurate,convenient and suitable for determining amlodipine besylatet and lisinopril simultaneously.

Key concepts: Amlodipine, Lisinopril, Chromatography, Chemistry, High-performance liquid chromatography, Gradient elution, Calibration curve, Detection limit

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HPLC Determination of Amlodipine Besylate and Lisinopril in Compound Amlodipine Tablets — Research Paper | ScholarLens