The Effect of Different Anastomotic Area in End-to-side Neurorrhaphy for Peripheral Nerve Injuries:An Experimental Study

Objective To study and compare the effect of different anastomotic area in end-to-side neurorrhaphy on rat peripheral nerve injuries repairing modelMethods 50 rats were randomized into 2 groups(A、B,n=25).In all groups,the peroneal nerve was transected and sutured in an end-to-side model.In A group,the distal end of the injured peroneal nerve was operated in an angle of 45 degrees;in B group,the distal end was operated in an angle of 10 degrees,and sutured in end-to-side neurorrhaphy to the donor nerve.Histological,electromyographic,muscle wet weight were analyzed.Myelinated nerve counts and Neuronal tracing with Dil were performed at the end of 8 weeks post operation.Results In B group,the muscle net weight,electromyography,myelinated nerre counts were performed than them in A group.The difference is significant(P0.05).Conclusion The larger Anastomotic area end-to-side neurorrhaphy can enhance axonal sprouting from the donor nerve,and improve the functional recovery.The anastomotic area is the important factors to the end-to-side coaptation model.