Protective Effects of Qingre Lishi Jianpi Decoction on Ulcerative Colitis Model Rats

OBJECTIVE:To study the protective effect of Qingre lishi jianpi decoction on ulcerative colitis rats. METHODS:The ulcerative colitis rat model was induced by the pump of TNBS(100 mg/kg)via anus. 75 SD rats were randomly divided into normal control group(constant volume of normal saline),model group(constant volume of normal saline),salazosulfapyridine group(0.27 g/kg),Qingre lishi jianpi decoction high-dose and low-dose groups(15.00,7.50 g/kg). They were given relevant medicines intragastrically once a day for consecutive 20 days. The disease activity index(DAI)was evaluated by observing the activity of rats. The levels of IL-6 and IL-10,SOD activity were detected. RESULTS:Compared normal control group,DAI and IL-6 content were increased while IL-10 content and SOD activity were decreased in model group;there was statistical significance(P0.05);compared with model group,DAI and IL-6 content were decreased while IL-10 content and SOD activity were increased in Qingre lishi jianpi decoction high-dose and low-dose groups group(P0.05). CONCLUSIONS: Qingre lishi jianpi can protect against ulcerative colitis model rats by reducing inflammatory factor and increasing the content of anti-inflammatory factor and SOD activity.