Characteristics of Trace Elements and Immune Function in Patients with Hepatic Cirrhosis and Correlativity Analysis

Objective To study the relationship between trace elements and immune function of patients with hepatic cirrhosis.Methods The level of the five serum trace elements in 52 patients with hepatic cirrhosis and 30 controls were detected by using Trace Element Detector,and the frequency of T-lymphocyte subsets in peripheral blood was detected by using Flow Cytometry.Results Compared with the control group,in the group of cirrhosis patients the serum Zn,Fe,Cr,Se levels were lower,and the serum Cu level was higher,especially at the decompensated stage(P0.05);CD3,CD4,NK cell levels in peripheral blood were lower,especially at the decompensated stage(P0.05).Linear correlation analysis showed:and CD3,CD4,NK cell levels were negatively correlated with serum Cu level,but positively correlated with serum Zn level(P0.05).Logistic regression analysis showed that Zn and Cuwere the relative risk factors for cirrhosis.Conclusion Apart from conventional therapy of protecting liver function,the detection and correction serum trace elements,immune function have important positive significance for assessing the condition and treatment of patients with hepatic cirrhosis.