Value of adenosine deaminase and carcinoembryonic antigen in differential diagnosis of pleural effusion

Objective To analyze the value of adenosine deaminase(ADA) and carcinoembryonic antigen(CEA) in the differential diagnosis of malignant pleural effusion,tuberculous pleural effusion and non-tuberculous benign pleural effusion.Methods We simultaneously detected ADA and CEA in malignant pleural effusion,tuberculous pleural effusion and non-tuberculous benign pleural effusion and then analyzed the detected data.Results(1)ADA in tuberculous pleural effusion was higher than that in malignant pleural effusion and non-tuberculous benign pleural effusion with statistical difference(P0.01).ADA in malignant pleural effusion and non-tuberculous benign pleural effusion had no statistical difference(P0.05).CEA in malignant pleural effusion was higher than that in tuberculous pleural effusion and non-tuberculous benign pleural effusion with statistical difference(P0.01).CEA in tuberculous pleural effusion and non-tuberculous benign pleural effusion had no statistical difference(P0.05).(2)ADA′s area under the ROC curve in diagnosis of tuberculous pleural effusion was 0.943.CEA′s area under the ROC curve in diagnosis of malignant pleural effusion was 0.927.Conclusion The detection of ADA and CEA has high value in the differential diagnosis of pleural effusion,which provides important information for clinical diagnosis and treatment.