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Placenta-derived mesenchymal stem cells for hypoxic ischemic brain damage in rats

Zhou Ming-q

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Abstract

Objective To investigate the effects of placenta-derived mesenchymal stem cells (PDMSCs) on hypoxic ischemic brain damage (HIBD) in rats and its mechanism. Methods Rats were randomized into control group, HIBD group, HIBD+PDMSCs group, and HIBD+fibroblasts group. After 2 weeks of treatment, the growth and nerve function were measured, and the expressions of HO-1 and Nrf2 gene and protein were detected by RT-PCR and Western Blot. Results As compared to those in control group, brain atrophy and neurological dysfunction were ameliorated and body weight was increased in HIBD+PDMSCs group (P 0.05). The expressions of HO-1 and Nrf2 gene and protein were increased from control group to HIBD group, and to HIBD+PDMSCs group (all P 0.05). All these index were significantly different between HIBD+fibroblasts group and HIBD+PDMSCs group (P 0.05). Conclusion PDMSCs may play a critical role in the neuroprotection in rats with HIBD through up-regulating Nrf2/ARE/HO-1 pathway.

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What this paper is about

Objective To investigate the effects of placenta-derived mesenchymal stem cells (PDMSCs) on hypoxic ischemic brain damage (HIBD) in rats and its mechanism. Methods Rats were randomized into control group, HIBD group, HIBD+PDMSCs group, and HIBD+fibroblasts group. After 2 weeks of treatment, the growth and nerve function were measured, and the expressions of HO-1 and Nrf2 gene and protein were detected by RT-PCR and Western Blot. Results As compared to those in control group, brain atrophy and neurological dysfunction were ameliorated and body weight was increased in HIBD+PDMSCs group (P 0.05). The expressions of HO-1 and Nrf2 gene and protein were increased from control group to HIBD group, and to HIBD+PDMSCs group (all P 0.05). All these index were significantly different between HIBD+fibroblasts group and HIBD+PDMSCs group (P 0.05). Conclusion PDMSCs may play a critical role in the neuroprotection in rats with HIBD through up-regulating Nrf2/ARE/HO-1 pathway.

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Available abstract

Objective To investigate the effects of placenta-derived mesenchymal stem cells (PDMSCs) on hypoxic ischemic brain damage (HIBD) in rats and its mechanism. Methods Rats were randomized into control group, HIBD group, HIBD+PDMSCs group, and HIBD+fibroblasts group. After 2 weeks of treatment, the growth and nerve function were measured, and the expressions of HO-1 and Nrf2 gene and protein were detected by RT-PCR and Western Blot. Results As compared to those in control group, brain atrophy and neurological dysfunction were ameliorated and body weight was increased in HIBD+PDMSCs group (P 0.05). The expressions of HO-1 and Nrf2 gene and protein were increased from control group to HIBD group, and to HIBD+PDMSCs group (all P 0.05). All these index were significantly different between HIBD+fibroblasts group and HIBD+PDMSCs group (P 0.05). Conclusion PDMSCs may play a critical role in the neuroprotection in rats with HIBD through up-regulating Nrf2/ARE/HO-1 pathway.

Key concepts: Brain damage, Neuroprotection, Mesenchymal stem cell, Western blot, Placenta, Internal medicine, Endocrinology, Andrology

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