Effect of Probiotics Drug in Treatment of Mild and Moderate Ulcerative Colitis

Objective To observe the clinical effects of probiotics drug in the treatment of mild and moderate ulcerative colitis.Methods Total 129 patients with mild to moderate active ulcerative colitis were divided into treatment group (65 patients) and control group (64 patients) at first stage.the former were treated with probiotics drug, the later were treated with mesalazine. the study lasted for 12 weeks and patients were assessed by clinical remission rate and the time to clinical remission.At second stage 91 patients in remission of ulcerative colitis were radomized into two groups to receive probiotics drug (43 patients in treatment group ) or mesalazine (48 patients in control group).After 12 months relapse-free time and relapse rate were determined.Results At first stage,after 12 weeks treatment there were no statistical differences(P0.05)between treatment group and control group in clinical remission rate and the time to clinical remission.At second stage, there were no differences between two groups(P0.05)in relapse-free time and relapse rate.Conclusion Probiotics drug are effective in treatment of mild and moderate active ulcerative colitis and preventing relapse.