Clinical Analysis on Combined Assay of Serum Tumor Markers in 96 Cases with Gastric Carcinoma

Objective To explore the clinical value of serum tumor markers in diagnosis,assessment of illness and curative effect,and prognosis of gastric carcinoma.Methods All 96 patients with gastric carcinoma and 36 patients with benign gastric disease were selected,and 6 kinds of serum tumor markers including CEA、CA50、CA15-3、CA19-9、CA125、CA242 were detected respectively.And patients with gastric cancer were followed up for 2 years.Results Four kinds of serum tumor markers including CEA、CA50、CA19-9、CA125 in gastric carcinoma group were significantly higher than control group(P0.01).Simultaneously combined assay can raise sensitivity(88.5%),and serial combined assaycan raise specificity(90.5%).Four kinds of tumor markers were higher in cases of phase Ⅲ and Ⅳ than in those of Ⅰand Ⅱ(P0.05).Also 4 kinds of tumor markers in group of relapse and metastasis were higher than that without relapse and metastasis(P0.05),and the level were rising gradually with prolonged follow-up.Conclusion It has some clinical value on diagnosis,assessment of illness and curative effect,and prognosis of gastric carcinoma by combined assay of serum tumor markers including CEA、CA50、CA19-9、CA125.