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2006•Chinese Journal of AIDS & STDRequires access

Clinical experimental study of lymphocyte apoptosis and CD_4~+T lymphocyte level in HIV/AIDS patients

Shao Hong

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Abstract

Objective To discuss the relationship between the percentages of lymphocyte apoptosis and the level of CD~+_4T lymphocyte in HIV/AIDS patients.Method The technique of flow cytometry was applied to detect apoptosis and CD~+_4 T lymphocyte counts in HIV/AIDS patients.Result The statistical difference was found in the rate of lymphocyte apoptosis among these two groups(F=898,P0.01),showing AIDSHIV infectedcontrol group(q_(12)=46,q_(13)=58,q_(23)=12,P0.01);statistical significance was also found in CD~+_4T lymphocyte counts(F=13 270,P0.01),showing control groupHIV infectedAIDS(q_(12)=33,q_(13)=203,q_(23)=185,P0.01).Conclusion The study shows certain correlation between CD~+_4 T lymphocyte level and lymphocyte apoptosis in HIV/AIDS patients,providing a useful clue for further research.

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What this paper is about

Objective To discuss the relationship between the percentages of lymphocyte apoptosis and the level of CD~+_4T lymphocyte in HIV/AIDS patients.Method The technique of flow cytometry was applied to detect apoptosis and CD~+_4 T lymphocyte counts in HIV/AIDS patients.Result The statistical difference was found in the rate of lymphocyte apoptosis among these two groups(F=898,P0.01),showing AIDSHIV infectedcontrol group(q_(12)=46,q_(13)=58,q_(23)=12,P0.01);statistical significance was also found in CD~+_4T lymphocyte counts(F=13 270,P0.01),showing control groupHIV infectedAIDS(q_(12)=33,q_(13)=203,q_(23)=185,P0.01).Conclusion The study shows certain correlation between CD~+_4 T lymphocyte level and lymphocyte apoptosis in HIV/AIDS patients,providing a useful clue for further research.

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Available abstract

Objective To discuss the relationship between the percentages of lymphocyte apoptosis and the level of CD~+_4T lymphocyte in HIV/AIDS patients.Method The technique of flow cytometry was applied to detect apoptosis and CD~+_4 T lymphocyte counts in HIV/AIDS patients.Result The statistical difference was found in the rate of lymphocyte apoptosis among these two groups(F=898,P0.01),showing AIDSHIV infectedcontrol group(q_(12)=46,q_(13)=58,q_(23)=12,P0.01);statistical significance was also found in CD~+_4T lymphocyte counts(F=13 270,P0.01),showing control groupHIV infectedAIDS(q_(12)=33,q_(13)=203,q_(23)=185,P0.01).Conclusion The study shows certain correlation between CD~+_4 T lymphocyte level and lymphocyte apoptosis in HIV/AIDS patients,providing a useful clue for further research.

Key concepts: Lymphocyte, Apoptosis, Flow cytometry, T lymphocyte, Human immunodeficiency virus (HIV), Immunology, Statistical analysis, Lymphocyte subsets

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