2008•Jiepouxue yanjiuRequires access

Study on plasma TNF level and TNFβG252A polymorphisnis in patients with Alzheimer's disease

Fan Hai-hon

Abstract

Objective To investigate the relationship between plasma levels of tumor necrosis factor(TNF) or its polymorphism and Alzheimer's disease. Methods Plasma level of TNF was measured by RIA,and the polymorphism of TNFβG252A gene was screened by PCR-RELP. Results The gene frequency of TNFβG252A in AD group was as followed; TNFβG252A 1/1, 1/2, 2/2 genotype frequency: 0.242, 0.591, 0.167; TNFβG252A 1 and TNFβG252A 2 genefrequency: 0.252, 0.573, 0.175. The gene frequency of TNFβG252A in control group was as followed; TNFβG252A 1/1, 1/2, 2/2, genotype frequency: 0.252, 0.573, 0.175,TNFβG252A 1, TNFβG252A 2 genefrequency: 0.9021, 0.0979. There was no significant differences in the frequencies of TNFβG252A gene between the patients and control group(P0.05). Alzheimer's group showed significantly higher plasma level of TNF than control group(P0.05). Plasma TNF increased in AD group. Conclusion TNF play important role in the process of AD and no evident association is found between TNFβG252A polymorphism and Alzheimer's disease.

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Key concepts: Tumor necrosis factor alpha, Genotype, Internal medicine, Plasma levels, Tumor necrosis factor α, Polymorphism (computer science), Disease, Medicine